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Celebrex can increase your risk of fatal heart attack or strokeespecially if you use it long term or take high dosesor if you have heart diseaseEven people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

NSAIDsincluding CELEBREX can lead to new onset of hypertension or worsening of preexisting hypertensioneither of which may contribute to the increased incidence of CV eventsPatients taking angiotensin converting enzymeACEinhibitorsthiazide diuretics or loop diuretics may have impaired response to these therapies when taking NSAIDssee DRUG INTERACTIONS

Some adverse reactions occurred in higher percentages of patients than in the arthritis pre-marketing trialstreatment durations up to 12 weekssee Adverse events from CELEBREX pre-marketing controlled arthritis trialsaboveThe adverse reactions for which these differences in patients treated with CELEBREX were greater as compared to the arthritis pre-marketing trials were as follows:

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