The risk of hypertension is increased if bupropion hydrochloride extended-release tablets xl are used concomitantly with maois or other drugs that increase dopaminergic or noradrenergic activity see contraindications 4 .

Information about Bupropion.
Risk of mydriasismay trigger angle closure attack in people with angle closure glaucoma with anatomically narrow angles without a patent iridectomyuse caution.
Antidepressants increased the risk of suicidal thinking and behaviorsuicidalityin short-term studies in children and adolescents with depression and other psychiatric disordersAnyone considering the use of bupropion or any other antidepressant in a child or adolescent must balance this risk with the clinical needPatients who are started on therapy should be closely observed for clinical worseningsuicidalityor unusual changes in behavior.
XL and SR tablets are intended for oral use only Inhaling crushed tablets or injecting dissolved tablets has been reported to cause seizures and/or death.
Some young people have thoughts about suicide when first taking an antidepressantStay alert to changes in your mood or symptomsReport any new or worsening symptoms to your doctor
Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitorsuch as isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilineor tranylcypromine.
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the mechanism of action of bupropion is unknown, as is the case with other antidepressants.